NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

At a glance

No plain-language summary yet for this grant — the official description below is the best source.

What it funds

Health
Research & Discovery
Researchers & Scholars
Biomedical & Disease Research

Official description from grants.gov

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund .

Who can apply

City or township governments
County governments
For-profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized)
Nonprofits with 501(c)(3) status (other than higher education)
Nonprofits without 501(c)(3) status (other than higher education)
Others
Private institutions of higher education
Public and State controlled institutions of higher education
Small businesses
Special district governments
State governments

Geographic restriction None found in the announcement — likely nationwide

Set-aside Set aside or prioritized for: Faith-based organization

“Faith-based or Community-based Organizations” — From the announcement

Change history

Jul 11, 2026 Title updated
Jul 11, 2026 Status: forecasted → open
Jul 11, 2026 Deadline set: Sep 3, 2026