At a glance
This notice is for projects that will generate and share omics data, including whole genome sequencing and other multi-omics data, for research on heart, lung, blood, and sleep disorders. Applicants must have existing high-quality biospecimens from well-phenotyped human subjects and agree to share data through NIH-controlled public databases like dbGaP and BioData Catalyst; clinical trials are not allowed. No funds are awarded under this X01 resource access award, and NHLBI intends to approve up to 10 projects with a maximum project period of 3 years. Eligible applicants include a wide range of U.S. and foreign organizations, but applications with foreign subawards or subcontracts are not allowed; cost sharing is not required.
What it funds
Official description from grants.gov
This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments