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HCN Grants Est. 2026
No. PAR-25-362 · National Institutes of Health
Open

Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This grant funds research on early immune system development in neonates, infants, children, and adolescents, especially in the context of HIV, anti-retroviral exposure, maternal and paternal immune status, and related factors such as the microbiome, co-infections, diet, metabolism, and obesity. Eligible applicants include a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profit organizations, and foreign organizations. Application budgets are limited to $400,000 per year in direct costs, excluding consortium F&A costs, and the project period can be up to four years. No cost sharing is required, and foreign components and non-domestic entities are allowed.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Children, Youth & Families
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
Official description from grants.gov

The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide