Skip to content
HCN Grants Est. 2026
No. PAR-25-068 · National Institutes of Health
Open

Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

grants.gov listing ↗ Full announcement (NOFO) ↗
Dealbreakers No cost share required
No audit required
“Required Registrations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award.” — From the announcement
Not reimbursement-only
“Funding Instrument Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds pilot and feasibility projects on basic or translational HIV research within the mission of NIDDK, including studies of biological, behavioral, environmental, psychological, and social factors that contribute to HIV pathogenesis and HIV-related comorbidities, coinfections, complications, and reservoirs. Eligible applicants include many U.S. organizations such as nonprofits, universities, governments, tribal organizations, community-based groups, and for-profit organizations, but foreign organizations and non-domestic components of U.S. organizations are not eligible. Awards are limited to a total of $275,000 in direct costs over two years, with no more than $200,000 in any single year. No cost sharing is required, and the NOFO does not accept clinical trial applications.

AI-generated summary — verify against the announcement

What it funds

  • Food and Nutrition
  • Health
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide