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HCN Grants Est. 2026
No. PA-25-301 · National Institutes of Health
Open

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This NIH grant funds discrete health-related research projects within the mission of participating NIH Institutes and Centers, and it does not accept applications proposing clinical trials. The application budget is not limited, but it must fit the actual needs of the project, and the project period can be up to 5 years. Many types of organizations can apply, including nonprofits, universities, governments, businesses, and foreign organizations, and foreign components are allowed. No cost sharing is required. Applications with foreign subawards or subcontracts are not allowed under this notice.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Environment
  • Food and Nutrition
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide