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HCN Grants Est. 2026
No. PAR-25-156 · National Institutes of Health
Open

Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)

grants.gov listing ↗ Full announcement (NOFO) ↗
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Invitation only
“This limited competition Notice of Funding Opportunity (NOFO) seeks to support novel approaches” — From the announcement

At a glance

This program funds high-impact, specialized innovation projects at CTSA UM1 hubs that create new resources, tools, technologies, methods, or discovery-based science to advance clinical and translational science. Only the primary UM1 hub organization can apply, and applications may come from an active CTSA UM1 hub; foreign organizations and non-domestic components of U.S. organizations are not eligible. Award budgets are limited to no more than $500,000 per year in direct costs, excluding consortium or contractual F&A costs, and the project period may be up to 5 years. Cost sharing is not required. A hub may submit up to two RC2 applications per cycle and may have up to two RC2 awards at a time; the RC2 is awarded only if the applicant organization has an awarded UM1.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Infrastructure, Construction & Shared Facilities
  • Researchers & Scholars
  • Health Care Delivery, Access & Workforce
  • Research Infrastructure, Instrumentation & Data
Official description from grants.gov

The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

Who can apply

  • Public and State controlled institutions of higher education
Geographic restriction None found in the announcement — likely nationwide