At a glance
This program funds development and/or validation of clinical outcomes and biomarkers for amyotrophic lateral sclerosis to help enrich clinical trials. Eligible applicants include U.S. Department of War organizations, foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities; independent investigators at eligible organizations may serve as principal investigators. The program expects to fund about seven awards at a total cost cap of $1.0 million per award, with a maximum project period of three years. Cost sharing is not required, clinical trials are not allowed, and applications are required to include community collaboration. There are no geographic restrictions stated beyond the eligibility of U.S. Department of War organizations and other foreign or domestic organizations.
What it funds
Official description from grants.gov
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in amyotrophic lateral sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients. Distinctive Features: To meet the intent of the funding opportunity, applications may address clinical biomarkers and/or clinical outcomes . This may include the identification, development, and/or validation of promising biomarkers for ALS, which may include, but are not limited to susceptibility/risk, diagnostic, monitoring/disease progression, prognostic, predictive, response, or safety biomarkers. Clinical Outcomes projects may focus on the identification, development, and/or validation of clinician-, observer-, or patient-reported, and/or performance outcome measures for ALS. Projects may include the optimization of current outcome measures already in use. Applications may utilize digital health measures, including wearable devices, smart-phone sensors, video or voice recordings, imaging studies, or other devices which record disease-relevant physiological data and/or outcomes. Community Collaboration is an important element of the FY26 ALSRP COBA. Applicants will be expected to articulate how the proposed research question or study design was informed by the ALS lived experience community.
Who can apply
- Unrestricted