At a glance
This program funds investigator-initiated research on inherited or acquired bone marrow failure diseases, including translational, clinical research, and IND-enabling studies, but it does not allow clinical trials. Applicants must include preliminary and/or published data relevant to bone marrow failure. Eligible applicants include U.S. Department of War organizations and foreign or domestic, for-profit or nonprofit organizations, and awards go to eligible organizations rather than individuals. The program expects to fund about one award, with total costs capped at $1.25 million and a maximum project period of 3 years. Cost sharing is not required, and the research must focus on bone marrow failure; primary focus on leukemia, myeloproliferative neoplasms, or other malignancies is not eligible.
What it funds
Official description from grants.gov
Summary: Supports studies that further develop mature ideas, expand upon key discoveries, and have the potential to make significant advances in bone marrow (BMF) failure research and/or patient care. Investigator-Initiated Research Award (IIRA) applications may involve translational and clinical research including studies in preclinical models, research with human data and/or anatomical substances, and research with human subjects, as well as correlative studies associated with a clinical trial(s); however, this award mechanism does not support clinical trials. IIRA applications may also support Investigational New Drug (IND)-enabling efforts such as lead compound characterization, and assessments of formulation and stability, absorption, distribution, metabolism and excretion, dose/response and toxicology. Distinctive Features: This funding mechanism allows for a partnering Principal Investigator (PI). Only the initiating PI will submit a pre-application, but both PIs will need to submit full applications. The partnering PI application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn. This award mechanism requires preliminary data relevant to the proposed project. Applications can support clinical research studies; however, this mechanism does not allow clinical trials.
Who can apply
- Unrestricted