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HCN Grants Est. 2026
No. PAR-25-311 · National Institutes of Health
Open

Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)

grants.gov listing ↗ Full announcement (NOFO) ↗
Dealbreakers No cost share required
No audit required
“This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1.2 Definition of Terms .” — From the announcement
Not reimbursement-only
“Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.” — From the announcement

At a glance

This program funds NICHD-supported, multisite clinical trials and observational studies for infants, children, women, including pregnant and lactating women, and persons with disabilities, using a two-phase UG3/UH3 award. It is open to a wide range of U.S. organizations, including nonprofits, universities, governments, tribal organizations, faith-based groups, and for-profit entities, but foreign organizations are not eligible. Applications must be investigator-initiated and use NICHD Network infrastructure, with some proposals needing a prior approved concept proposal. Direct costs are limited to $6,250,000 for the full project period, which can be up to 7 years total, with up to 2 years for UG3 and up to 5 years for UH3.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Children, Youth & Families
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
  • Disability Services & Assistive Technology
  • Maternal, Child & Reproductive Health
Official description from grants.gov

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide