Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed)

At a glance

This program funds preclinical development of therapeutic agents for neurological or neuromuscular disorders, including characterization, pharmacokinetic studies, pharmacodynamic studies, and in vivo efficacy studies. It supports small molecules and biologics such as peptides, proteins, oligonucleotides, gene therapies, and cell therapies, but not optimization, IND-enabling work, clinical studies, or basic disease mechanism research. Eligible applicants include U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profits, and small businesses, and foreign organizations and foreign components are allowed. Direct costs cannot exceed $499,000 in any one year and $750,000 over the full three-year project period, with no more than two years in either the R61 or R33 phase. No cost sharing is required, and clinical trials are not allowed.

AI-generated summary — verify against the announcement

What it funds

Health
Research & Discovery
Technology & Product Development
Patients & People with Health Conditions
Biomedical & Disease Research

Official description from grants.gov

Reissue PAR-21-122. This NOFO provides funding to conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological or neuromuscular disorders that fall under the NINDS mission. Therapeutic agents include small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network or other translational programs.

Who can apply

City or township governments
County governments
For-profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized)
Nonprofits with 501(c)(3) status (other than higher education)
Nonprofits without 501(c)(3) status (other than higher education)
Others
Private institutions of higher education
Public and State controlled institutions of higher education
Public housing authorities / Indian housing authorities
Small businesses
Special district governments
State governments

Geographic restriction None found in the announcement — likely nationwide