Skip to content
HCN Grants Est. 2026
No. PAR-24-264 · National Institutes of Health
Open

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds institutions to buy or upgrade a single high-end, commercially available research instrument or integrated system for biomedical research, and the instrument must be dedicated to biomedical research only. Eligible applicants include higher education institutions and certain nonprofits; foreign organizations are not eligible, and foreign components are not allowed. Awards range from $750,001 to $2,000,000, last one year, and do not allow indirect costs. Cost sharing is not required, but special use instrument requests require the non-NIH share to be at least 25% of the total instrument price and the biomedical research time to meet stated minimums. At least three major users with distinct active NIH research awards must be identified, and each application may request only one type of instrument; applications requesting more than one instrument type are not responsive.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Infrastructure, Construction & Shared Facilities
  • Researchers & Scholars
  • Biomedical & Disease Research
  • Research Infrastructure, Instrumentation & Data
Official description from grants.gov

The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $750,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, nuclear magnetic resonance spectrometers, X-ray diffractometers, mass spectrometers, high throughput robotic screening systems, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.

Who can apply

  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
Geographic restriction None found in the announcement — likely nationwide