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HCN Grants Est. 2026
No. PAR-25-285 · National Institutes of Health
Open

Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated Reimbursement-only: not stated

At a glance

This funding opportunity supports milestone-based R61 planning and infrastructure work followed by an R33 clinical trial to test system-level interventions or strategies that improve the organization, delivery, coordination, access, quality, and outcomes of mental health care. Eligible applicants are not stated in the text, but the project must be an NIH-defined clinical trial and is intended for routine care, community, school, online, or similar real-world settings, not academic research settings alone. The total project period cannot exceed 5 years, with up to 2 years for the R61 phase and up to 4 years for the R33 phase if milestones are met; it does not state a cost-share requirement. The announcement emphasizes system-level interventions rather than individual-level training-only approaches and encourages research addressing disparities, including for racial and ethnic minority groups, rural residents, and other underserved groups.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Children, Youth & Families
  • General Public / Community-wide
  • Patients & People with Health Conditions
  • Health Care Delivery, Access & Workforce
  • Mental & Behavioral Health
Official description from grants.gov

This R61/R33 concept complements NIMHs suite of clinical trial NOFOs by supporting feasibility and infrastructure development (R61) followed by well-powered clinical trials (R33) to test the effectiveness of system interventions and strategies for improving the organization, delivery, coordination, and clinical and functional outcomes of mental health services. System interventions - which may span, for example, structural, policy, organizational, and interpersonal domains - attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety of mental health services, with the goal of improved care processes and clinical and functional outcomes. Accordingly, the focus of system interventions may include a variety of care settings, such as health systems and organizations, mental health and community clinics, schools, and child welfare or juvenile justice systems

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide