At a glance
This program funds exploratory research to develop and test novel psychosocial interventions for the treatment or prevention of mental disorders in adults and children, including in-person or technology-assisted approaches. It is for new, resubmitted, or revised applications that include clinical trials, and it supports studies that examine whether an intervention changes a defined target and shows a preliminary clinical benefit. NIMH intends to commit a total of $27,000,000 for FY 2026 across this notice and related companion notices. Award budgets are not limited but must match the actual needs of the project, and support is available for up to 3 years. The notice does not state any cost-share requirement or geographic restriction.
What it funds
Official description from grants.gov
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments