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HCN Grants Est. 2026
No. PAR-25-207 · National Institutes of Health
Open

Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated Reimbursement-only: not stated

At a glance

This program funds effectiveness trials of post-acute interventions and services for mental health conditions in youth, adults, and older adults. Applicants may include universities, nonprofits, governments, small businesses, faith-based and community-based organizations, and foreign organizations; foreign components of U.S. organizations are also allowed. Awards are not limited in size, the number of awards depends on NIH appropriations and the quality of applications, and projects may run up to 5 years, though most awards are expected to be 3 to 4 years. The announcement does not state a cost-share requirement. It specifically excludes studies of acute-phase interventions and limits funding to clinical trials with prospective assignment to intervention conditions.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Older Adults & Family Caregivers
  • Patients & People with Health Conditions
  • Mental & Behavioral Health
Official description from grants.gov

NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes. This NOFO is intended to support effectiveness trials testing post-acute phase interventions that are statistically powered to provide a definitive answer regarding the study intervention's effectiveness. Support for pilot effectiveness trials to evaluate the initial feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches is provided via a companion R34 (Currently TEMP-24814)

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide