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HCN Grants Est. 2026
No. PAR-25-282 · National Institutes of Health
Open

Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated Reimbursement-only: not stated

At a glance

This program funds mechanistic and translational research on the onset and worsening of mood disruption and psychosis during the menopausal transition, including studies of underlying biology, behavior, and social factors. Eligible applicants include a wide range of organizations such as universities, nonprofits, governments, tribal entities, small businesses, for-profits, and foreign organizations, and foreign components are allowed. The award is a grant with a maximum of $275,000 in direct costs over two years, with no more than $200,000 in any single year. Cost sharing is not required. Projects must target people transitioning through menopause, and studies that are only descriptive, focus on intervention safety or effectiveness, use only one level of analysis, or involve nonhuman animals are not responsive.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Aging, Dementia & Caregiving
  • Biomedical & Disease Research
  • Mental & Behavioral Health
Official description from grants.gov

The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the MT. Aspects of mood and psychosis disorders that are of interest include: classic depressive symptoms in combination with menopause symptoms (e.g., hot flashes, night sweats, sleep disturbance) and psychological challenges, the role of reproductive steroids in the regulation of mood and behavior during the MT, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, appreciation of psychosocial factors common in midlife, and differential diagnoses. Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide