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HCN Grants Est. 2026
No. PAR-25-378 · National Institutes of Health
Open

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds planning and development studies for interventions to improve the health of Native populations, including pilot or feasibility research ahead of a future clinical trial. It is open to a wide range of U.S. organizations, including nonprofits, tribal governments, schools, governments, small businesses, and faith-based or community-based organizations; foreign organizations and non-U.S. components of U.S. organizations are not eligible. Applicants may request up to $450,000 in direct costs over three years, with no more than $225,000 in direct costs in any single year. No cost sharing is required. The announcement does not list a geographic restriction, but projects must be community-engaged and focused on Native populations, including American Indian, Alaska Native, Urban Indian, and Native Hawaiian communities as defined in the notice.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Environment
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Tribal & Indigenous Communities
  • Biomedical & Disease Research
  • Health Care Delivery, Access & Workforce
  • Public Health, Prevention & Nutrition
Official description from grants.gov

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide