At a glance
This grant funds screening, functional validation, and characterization of genomic variants linked to human congenital anomalies, including structural congenital anomalies, intellectual developmental disabilities, and inborn errors of metabolism. Eligible applicants include a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profits, small businesses, and foreign organizations. NIH says awards and total funding depend on appropriations and the number of meritorious applications; application budgets are limited to $499,999 in direct costs per year, with a project period of up to 5 years. No cost sharing is required, clinical trials are not allowed, and foreign components and foreign organizations are allowed.
What it funds
Official description from grants.gov
Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments