Skip to content
HCN Grants Est. 2026
No. PAR-25-081 · National Institutes of Health
Open

National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

grants.gov listing ↗ Full announcement (NOFO) ↗
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds investigator-initiated early phase cancer clinical trials, including Phase 0, I, and II studies of diagnosis and treatment interventions. It is for R01 applications and accepts only clinical trials; phase III trials, observational studies, and studies that do not meet the NIH clinical trial definition are not responsive. Eligible applicants include U.S. and foreign organizations, nonprofits, universities, governments, small businesses, and other listed entity types, and foreign components are allowed. Application budgets are limited to no more than $499,999 in direct costs per year, the project period can be up to 5 years, and no cost sharing is required. There is no stated geographic restriction, but the trials must be relevant to NCI’s Division of Cancer Treatment and Diagnosis and/or the Office of HIV and AIDS Malignancies.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
Official description from grants.gov

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide