At a glance
This program funds pilot hybrid effectiveness-implementation trials of mental health interventions and related implementation strategies in routine care, community, school, or online settings. It supports work to optimize, personalize, augment, or sequence prevention or treatment approaches, and applicants must evaluate both clinical outcomes and at least one hypothesized mechanism of action. Eligible applicants include a wide range of U.S. and foreign organizations, including nonprofits, schools, governments, for-profits, and tribal organizations, and foreign components are allowed. NIMH intends to commit $27 million in FY 2026 for this NOFO and companion announcements, with direct costs limited to $750,000 over up to three years and no more than $250,000 in any single year. No cost sharing is required.
What it funds
Official description from grants.gov
Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R01 Clinical Trial Required). As part of NIMH's clinical trials pipeline NOFOs, this announcement encourages pilot effectiveness studies focused on 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support pilot studies of intervention effectiveness or service delivery approaches that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.).
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments