At a glance
This program funds early-stage psychosocial intervention development and testing for mental disorders in adults and children, using a phased R61/R33 clinical trial approach. Applicants must propose a novel target, mechanism, or intervention strategy, and the study must measure whether the intervention changes that target or mechanism. The R61 phase supports up to 2 years, with the possibility of up to 3 additional years in the R33 phase if R61 milestones are met. The announcement does not state a cost-share requirement, and it limits work on novel pharmacologic interventions, neuromodulatory devices, broad societal exposures like poverty or violence, nonhuman animal studies, and simple translation of existing interventions to technology platforms.
What it funds
Official description from grants.gov
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments