Skip to content
HCN Grants Est. 2026
No. PAR-25-266 · National Institutes of Health
Open

Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Funding Instrument Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds exploratory research on new newborn screening methods, assays, treatments, and related studies for conditions already on newborn screening panels or conditions that may be added soon. Eligible applicants include a wide range of U.S. and non-U.S. organizations, including nonprofits, colleges, governments, businesses, tribal organizations, and foreign organizations. The total direct costs for the two-year project period may not exceed $275,000, with no more than $200,000 in any single year, and the number of awards depends on NIH funding and the quality of applications. No cost sharing is required, and foreign components and foreign organizations are allowed.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
  • Maternal, Child & Reproductive Health
Official description from grants.gov

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide