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HCN Grants Est. 2026
No. PAR-25-065 · National Institutes of Health
Open

Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)

grants.gov listing ↗ Full announcement (NOFO) ↗
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program supports biomedical, behavioral, and social science research on the mechanisms behind neuropsychiatric symptoms in people with Alzheimer’s disease or related dementias, including mechanistic clinical trials and studies on treatment response biomarkers. Eligible applicants include a wide range of U.S. and foreign organizations, including nonprofits, universities, governments, small businesses, and faith-based or community-based organizations. The award budget is not limited, the project period can be up to 5 years, and the number of awards depends on NIH appropriations and the quality of applications. No cost sharing is required, and foreign organizations, non-U.S. components of U.S. organizations, and foreign components are allowed.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Aging, Dementia & Caregiving
  • Biomedical & Disease Research
  • Mental & Behavioral Health
Official description from grants.gov

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide