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HCN Grants Est. 2026
No. RFA-AT-25-003 · National Institutes of Health
Open

HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds small-scale basic and mechanistic pain research and may also support mechanistic clinical trials, along with partnerships that add resources or expertise from a separate U.S. domestic institution. It is for R15-eligible public or nonprofit higher education institutions that grant health professions or biomedical and behavioral degrees, and the main investigator must be from the R15-eligible institution. Applicants may request up to $375,000 in direct costs for the full project period, with up to 3 years of support, and NIH expects up to three awards per year in FY 2026 and FY 2027. No more than one third of the total budget may go to subawards or non-R15-eligible institutions, and the program is limited to U.S. domestic partnering institutions; foreign organizations are not eligible to apply.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Training, Fellowship & Career Development
  • Researchers & Scholars
  • Students & Learners (K-12 and Postsecondary)
  • Biomedical & Disease Research
  • Higher Education Access, Institutions & Humanities
Official description from grants.gov

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Who can apply

  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
Geographic restriction None found in the announcement — likely nationwide