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HCN Grants Est. 2026
No. PAR-25-353 · National Institutes of Health
Open

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.” — From the announcement

At a glance

This program supports cooperative agreements for research on new drugs, biologics, devices, and related tools for mental disorders, including discovery, preclinical work, early human studies, and proof-of-concept testing. Academic, nonprofit, industry, and other listed U.S. organizations may apply, but foreign organizations and non-U.S. components of U.S. organizations are not eligible; foreign components are allowed. Awards are not capped, the number of awards depends on NIH appropriations and merit, and the project period may not exceed five years. No cost sharing is required.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
  • Mental & Behavioral Health
  • Substance Use & Addiction
Official description from grants.gov

Reissue of PAR-20-119. This FOA encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This FOA supports a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. Projects seeking support for a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies should consider the companion U01 FOA.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide