At a glance
This program supports preclinical studies to test existing or investigational drugs, drug combinations, and some combinations with non-drug interventions for Alzheimer’s disease and related dementias. Applicants must be eligible organizations such as nonprofits, universities, governments, businesses, tribal entities, and foreign organizations, and clinical trials are not allowed. NIA plans to spend $6 million in fiscal year 2026 for 4 to 5 awards, with budgets capped at $1 million in direct costs per year and project periods up to 5 years. No cost sharing is required, and foreign organizations and foreign components of U.S. organizations are allowed.
What it funds
Official description from grants.gov
This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments