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HCN Grants Est. 2026
No. PAR-25-100 · National Institutes of Health
Open

Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This grant funds pilot and preliminary research to prepare for larger studies on ways to improve access to, quality of, effectiveness of, affordability of, and use of tobacco or substance use disorder treatment and related services. It is for a wide range of applicants, including universities, nonprofits, for-profits, governments, tribal entities, faith-based and community organizations, and foreign organizations. Direct costs are limited to $450,000 over three years, with no more than $225,000 in direct costs in any one year, and the project period may not exceed three years. No cost sharing is required. Applications involving alcohol alone are not eligible.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Health Care Delivery, Access & Workforce
  • Mental & Behavioral Health
  • Substance Use & Addiction
Official description from grants.gov

This Notice of Funding Opportunity (NOFO) encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials. Relevant trials may test a wide range of approaches, including interventions, practices, and policies designed to optimize access to, and the quality, effectiveness, affordability and utilization of drug, tobacco, or alcohol use disorder treatments and related services, as well as services for comorbid medical and mental disorder conditions. Relevant approaches may include both those that are novel, and those that are commonly used in practice but lack an evidence base. This NOFO provides resources for assessing the feasibility, acceptability, and utility of these approaches, in addition to usual trial preparation activities.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide