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HCN Grants Est. 2026
No. PA-25-305 · National Institutes of Health
Open

NIH Research Project Grant (Parent R01 Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This NIH grant supports a discrete health-related research project and requires the application to propose one or more clinical trials. Eligible applicants include U.S. and foreign organizations such as universities, nonprofits, governments, small businesses, and tribal entities, and foreign components are allowed, but applications with foreign subawards or subcontracts are not eligible. There is no set budget limit, the project period can be up to 5 years, and NIH did not state a fixed number of awards. No cost sharing is required.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Environment
  • Food and Nutrition
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
Official description from grants.gov

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide