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HCN Grants Est. 2026
No. PAR-25-057 · National Institutes of Health
Open

NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.” — From the announcement

At a glance

This program funds investigator-initiated clinical trials for dental, oral, and craniofacial diseases or conditions, including trials of drugs, biologics, devices, procedures, diagnostics, and other interventions. It uses a one-year UG3 planning phase and may continue into up to five years of UH3 trial implementation if milestones are met; the first phase does not guarantee the second. Eligible applicants include U.S. higher education institutions, nonprofits, for-profits, governments, tribal entities, faith-based and community-based organizations, and some federal and other U.S. entities, but foreign organizations and non-U.S. components of U.S. organizations are not eligible to apply. Application budgets are limited to less than $400,000 in direct costs for the UG3 phase, while UH3 budgets are not limited; no cost sharing is required. Delayed onset studies are not supported, and applications involving multiple domestic sites are subject to the NIH Single IRB policy.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
Official description from grants.gov

To support UG3/UH3 phased, cooperative agreement research applications to plan and implement clinical trials within the mission of the National Institute of Dental and Craniofacial Research (NIDCR)

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide