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HCN Grants Est. 2026
No. PA-25-306 · National Institutes of Health
Open

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This NIH grant funds exploratory and developmental research projects that are novel and may test new ideas, methods, model systems, tools, agents, targets, or technologies. Applications must propose clinical trial(s), and NIH says some institutes will only accept mechanistic clinical trials through this opportunity. A wide range of organizations may apply, including nonprofits, universities, governments, for-profits, small businesses, tribal governments, and foreign organizations, but applications involving foreign subawards or subcontracts are not allowed. The combined direct-cost budget for the two-year project period may not exceed $275,000, with no more than $200,000 in any single year. Cost sharing is not required.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Environment
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide