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HCN Grants Est. 2026
No. PAR-23-286 · National Institutes of Health
Open

NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs.” — From the announcement

At a glance

This program supports mentored postdoctoral training followed by independent research for early-stage researchers who are moving toward tenure-track or equivalent faculty jobs. It does not allow applications proposing an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, though applicants may gain experience in a mentor-led trial. The K99 phase can support up to 2 years with salary up to $100,000 per year and up to $30,000 per year for research development costs, and the R00 phase can support up to 3 more years with total costs not to exceed $249,000 per year. No cost sharing is required. Eligible applicants include a wide range of U.S. institutions and organizations, but foreign institutions and non-U.S. components of U.S. organizations are not eligible.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Training, Fellowship & Career Development
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The purpose of the NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00) program is to increase and maintain a strong cohort of new and talented, NCI-supported, independent investigators. This program is designed for postdoctoral fellows with research and/or clinical doctoral degrees who do not require an extended period of mentored research training beyond their doctoral degrees. The objective of this award is to facilitate a timely transition of these fellows from their mentored, postdoctoral research positions to independent tenure-track (or equivalent) faculty positions. The program will provide independent NCI research support during this transition to help awardees to launch competitive, independent research careers. Researchers in the scientific areas of cancer control, cancer prevention and cancer data sciences are especially encouraged to work with their institutions to apply. This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Under this NOFO candidates are permitted to propose a research experience in a clinical trial led by a mentor or co-mentor. Those proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion NOFOs (PAR-23-287 or PAR-23-288).

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide