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HCN Grants Est. 2026
No. PAR-23-287 · National Institutes of Health
Open

NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program supports postdoctoral researchers who are moving from mentored training to independent faculty positions and aims to build an independent research program in cancer-related fields. It is only for applications proposing an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. The award provides up to 5 years of support in two phases: up to 2 years for the mentored K99 phase and up to 3 years for the independent R00 phase; NCI will contribute up to $100,000 per year for K99 salary and up to $30,000 per year for K99 research development costs, and the R00 phase may not exceed $249,000 per year in total cost. No cost sharing is required, foreign institutions are not eligible, and applications with foreign subawards or subcontracts will not be considered. Eligible applicants must be in mentored postdoctoral positions with no more than 2 years of postdoctoral research experience, and each eligible institution may submit up to four applications total across this and companion NOFOs, with one per listed cancer research area.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Training, Fellowship & Career Development
  • Patients & People with Health Conditions
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The purpose of the NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00) program is to increase and maintain a strong cohort of new and talented, NCI-supported, independent investigators. This program is designed for postdoctoral fellows with research and/or clinical doctoral degrees who do not require an extended period of mentored research training beyond their doctoral degrees. The objective of this award is to facilitate a timely transition of these fellows from their mentored, postdoctoral research positions to independent tenure-track (or equivalent) faculty positions. The program will provide independent NCI research support during this transition to help awardees to launch competitive, independent research careers. Researchers in the scientific areas of cancer control, cancer prevention and cancer data sciences are especially encouraged to work with their institutions to apply. This notice of funding opportunity (NOFO) is designed specifically for candidates proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial, as part of their research and career development. Those not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion NOFO (PAR-23-286).

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide