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HCN Grants Est. 2026
No. PAR-25-064 · National Institutes of Health
Open

Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Funding Instrument Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds biomedical, behavioral, and social science research on the causes and mechanisms of neuropsychiatric symptoms in people with Alzheimer’s disease or related dementias, including mechanistic clinical trials. It is open to a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, small businesses, and foreign organizations, and foreign components of U.S. organizations are allowed. The award is a grant for a two-year project period, with no more than $275,000 in direct costs total and no more than $200,000 in any single year. Cost sharing is not required.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Older Adults & Family Caregivers
  • Aging, Dementia & Caregiving
  • Biomedical & Disease Research
  • Mental & Behavioral Health
Official description from grants.gov

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advanceadavnce mechanistic understanding of both biobehavioral and neurobiologfical pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide