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HCN Grants Est. 2026
No. PAR-25-287 · National Institutes of Health
Open

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

At a glance

This program funds engineering and pre-clinical development of new brain stimulation devices and related hardware or software for mental health uses, including major improvements to existing FDA-approved or cleared devices. It is open to a wide range of applicants, including nonprofits, universities, for-profit companies, small businesses, governments, tribal organizations, foreign organizations, and faith-based or community-based organizations. The funding uses grants, with no limit on the application budget, a maximum project period of 5 years, and no cost sharing required. Clinical trials are not allowed, and the notice says foreign organizations and foreign components of U.S. organizations may apply.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Technology & Product Development
  • Patients & People with Health Conditions
  • AI, Computing & Cybersecurity
  • Biomedical & Disease Research
  • Mental & Behavioral Health
Official description from grants.gov

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates) are not withinthe scope of this announcement.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide