At a glance
This program funds phased research to develop and validate screening assays and then use them to identify potential therapeutic agents for neurological or neuromuscular disorders. It supports R61 activities such as assay setup, optimization, validation, and pilot screening, and R33 activities such as high-throughput screening and preparation of focused hits, but it does not support assay optimization for therapeutic agents, medicinal chemistry optimization, disease mechanism studies, in vivo proof-of-concept efficacy studies, or clinical trials. Eligible applicants include a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profits, small businesses, and foreign organizations, and foreign components of U.S. organizations are allowed. Direct costs cannot exceed $499,000 in any one year and $750,000 over the three-year project period, with no cost sharing required. Applications must separate the R61 and R33 phases and include quantitative go/no-go milestones; the number of awards is contingent on funding and meritorious applications.
What it funds
Official description from grants.gov
This funding opportunity announcement (FOA) encourages research grant applications to develop in vitro and/or ex vivo assays and conduct iterative screening efforts to identify and characterize potential therapeutic agents for neurological or neuromuscular disorders. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network (BPN) or other translational programs.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments