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HCN Grants Est. 2026
No. RFA-DA-27-004 · National Institutes of Health
Open

BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated Reimbursement-only: not stated

At a glance

This program funds new theories, computational models, and analysis methods for complex brain data, with an emphasis on tools that help explain or predict how the brain works. Eligible applicants include U.S. and non-U.S. institutions, nonprofits, for-profits, small businesses, governments, and tribal organizations; foreign organizations and foreign components are allowed, but applications with foreign subawards or subcontracts are not eligible. NIH expects about $6 million per year to support up to 15 awards each year, with budgets generally expected to be between $150,000 and $350,000 in direct costs per year for three years. No cost sharing is required. The award is for research that does not involve clinical trials.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Researchers & Scholars
  • AI, Computing & Cybersecurity
  • Biomedical & Disease Research
Official description from grants.gov

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide